Harley Street, London
What is nucleofill and how does it help aging?

Its main indication is the treatment of facial aging as it reverses the effects of skin laxity associated
with age.
It has the following effects:
✓ Bioremodelation: with the concentration of Nucleofill 2% we have the possibility of
intervening on skin laxity.
✓ Bioregenerating the dermis and stimulating the synthesis of collagen and elastin. This will
stimulate the fibroblast and achieve a neoformation of the dermal matrix, as well as a
restructuring thereof – thanks to the formation of type I collagen.
✓ Hydrolifting: hydrating and stimulating the production of endogenous hyaluronic acid.
✓ Support in the mechanical remodeling of the dermis.

Anyone suffering from under-eye bags knows how hard it is to find an effective treatment. Indeed, bags under the eye or hollows tear through make you look tired and older.

As you know, the periocular area is an extremely delicate area that tends to age quicker compared to the rest of the face. Additionally, it is continuously subjected to environmental pollution and to facial expressions movement. Hence, creating fine lines and wrinkles.

Nucleofill has beneficial properties at different levels:
✓ Increased synthesis of collagen in keratinocytes;
✓ Increase in elastin synthesis (by fibroblasts and keratinocytes);
✓ Increase in fibroblast synthesis;
✓ Feeding of the dermis cells;
✓ Improvement of the elasticity of the skin;
✓ Less inflammatory response;
✓ Prolonged action over time.

The effect of Nucleofill

Specifically, the active ingredient of the Nucleofill has a triple action: Lifting, antioxidant, and hydration:

1) Indeed, the first course of action is the receptor of fibroblasts in the skin. Thanks to this stimulation,  the production of type I collagen and elastin is increased. Consequently, this helps to thicken and lift the skin.

2) Furthermore, the second effect is the “scavenging” of free radicals and antioxidant activity. As a consequence, it protects from oxidative stress (pollution, sun exposure, smoking, poor diet).

3) Lastly, the Polynucleotides bind water and give deep hydration leaving the skin moisturized and supple.

" My motto is less is more"

Rupesh Shah

What is Nucleofill for the under-eyes?

Firstly, Nucleofill is a new injectable biorevitalisation treatment, designed to improve skin microcirculation, provide deep moisture, firm, and contour.

Nucleofill Eye is specially formulated for use in the delicate periocular area. Indeed, it helps address undereye puffiness, fine lines and wrinkles, and even volume loss

What does Nucleofill contain?

So, this treatment contains a highly purified Polynucleotide matrix which works to hydrate, reduce free radical damage and boost collagen production. Consequently, Nucleofill activates bio-regeneration at the dermis (fibroblast stimulation) and deeper level (adipose and bone tissue).

How does Nucleofill eye works?

Nucleofill is a preparation for deep renewal and biostimulation of the skin, developed on the basis of natural polynucleotides.

Furthermore, the high-density but low molecular weight structure allows a fast penetration in tissues. As a result, it creates an effective stimulation of the periocular area.

In short, it effectively revitalizes the under-eye area with visible results. Also, it can be a good alternative to tear through fillers.

What are the effects of the Nucleofill eye?

This innovative treatment works on three levels:

– Lifting:  stimulates the process of collagen type I and elastin production, which causes thickening of the skin and its lifting;
– Antioxidant effect and elimination of free radicals;
– Moisturizing effect: thanks to the binding water by polynucleotides.

Additionally, there are three types of effects from Nucleofill Eye:

1) Impact at the dermo-epidermal layer;

2) Effect at the vascular level;

3) And finally, an effect at the level of deep tissues.

In conclusion, your under-eye area is visibly improved. In our view, this is one of the best treatments for the periocular area we have seen.

Benefits of Nucleofill

The Nucleofill Eye is specifically designed to improve:

• Puffiness / Bags under eyes

• Periocular wrinkles

• Regenerate the skin in the Periocular area

• Bio-restructuration of deep tissues

• Improvement of superficial wrinkles without the use of fillers

• Pre and post-surgical treatment (such as Blepharoplasty, surgical eye lift, laser).

Note that it is suitable for all skin types and all ages.


1. SPECIALIST PRACTITIONER: You will be consultated and treated by Rupesh. You don't see different people along your treatment journey. Rupesh starts of with your consultation and finishes of with your treatment and aftercare.

2. SERVICE & CARE: Rupesh prides himself on patient care and experience, therefore, he will ensure that your visit and treatment is as informative, comfortable and professional as possible.

3. CLINIC LOCATION: The treatment is carried out at our clinic in the world famous Harley Street in London. We are based a 5 minute walk from Bond Street tube station.

4. HIGH PATIENT SATISFACTION: Rupesh's patients are very happy with their results resulting in many returning to have additional areas. You can see many of his positive reviews on google.

5. PREMIUM PRODUCTS: We use only premium and MHRA approved products for the treatment like BOTOX, JUVEDERM, DERMAPEN, THE PERFECT PEEL.

6. SAVEFACE REGISTERED and approved. This ensures that we carry out treatments, hygiene and patient care to the highest of standards.


With our Harley Street address our prices are highly competitive ( probably the most competitive in London!)

We have a number of payment options to include the prestigious AMERICAN EXPRESS CARD.

With the industry’s best qualified professional practitioner who operate on the latest and safest techniques you can be sure you are in the best hands.

Call today for your free consultation:

Private London Clinic based in central London’s prestigious Harley Street known for its safety and high quality can book appointments for you on weekends and weekday evenings.

Procedure Time
20 minutes estimated 

Back To Work
1-3 days


Full Recovery
1 weeks estimated


Duration Of Results

Risks & Complications
swelling, redness, bruising and tenderness

Following a Celluform treatment it is completely normal to experience swelling and bruising around the treated area. Once this has settled the skin can begin to feel loose and ‘jelly’ like but this will tighten over time. We recommend following a healthy diet and drinking 2-3 litres of water per day throughout the course of treatment and to massage the area once or twice daily.
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You will be charged if you dont arrive in time or cancel your appointment last minute.
Please note: Before & After photos are not guarantees that your results will be the same or even similar, each individual patient's results will vary
Private London Clinic, Harley Street, London is a Save Face Accredited clinic.
 Our Sister Clinic: London Lip Clinic

Registered Pharmacy:
GPhC Premises Reg No. : 9011544

Private London Clinic by Rupesh
Contact us to arrange a consultation
London clinic
10 Harley Street, London, W1G 9PG
020 7193 9717
07956 576666
Opening Hours
9am - 9pm
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